Comment by OldfieldFund

LD50 in sheep:

1–5 mg/kg IV

1–2 mg/kg SC

85 mg/kg O

In mice:

75–115 mg/kg IP

48 mg/kg IV

113 mg/kg SC

278 mg/kg O

They were administering over 30mg to humans in trials. (Metzner (2013); Shulgin and Shulgin (1997); Ott (2001); Davis et al. (2018); Uthaug et al. (2020a))

Sheep are susceptible to toxicity from certain tryptamine alkaloids because of their physiology.

These alkaloids, especially those that are N,N-dimethylated, can trigger neurological symptoms in sheep, such as convulsions, spasticity, and gait issues. The alkaloids are suspected to affect the brain and spinal cord by interacting with serotonin receptors.

5-MeO-DMT is an N,N-dimethylated compound. Its full chemical name is 5-methoxy-N,N-dimethyltryptamine. That indicates the presence of two methyl groups attached to the nitrogen atom of the tryptamine backbone.

Stay safe, everyone!