Comment by shayway

Another aspect to consider is how quickly tolerance builds. After a few weeks of regular low psilocybin doses, even what's considered a high dose can have little to no noticeable effects. Taking equivalent amounts in the study isn't as far-fetched as it might seem, given a few weeks/months of tolerance building.

The question remains though: would it still have the same effects? The psychological effects are certainly diminished with tolerance, but who knows if this study's findings act on the same/a similar mechanism.