Comment by phtrivier
4 days ago
So, what products would work as "sleep in a pill", at least on the "not being exhausted" part (I suppose the "not getting crazy because of lack of REM sleep" would be different) ?
4 days ago
So, what products would work as "sleep in a pill", at least on the "not being exhausted" part (I suppose the "not getting crazy because of lack of REM sleep" would be different) ?
Speculative: Gentle mitochondrial uncouplers that cross the BBB very well, possibly in conjunction with elamipretide, MitoQ, MitoTEMPO, or something similar.
Would these also have a thermogenesis effect? I used that hyper deadly illegal one (can’t remember the name, very yellow) several years ago and got a sauna in my torso (shredded abs too) but didn’t notice any perceptual energy balance change.
Yeah, probably.
DNP (2,4-Dinitrophenol) is the stuff you took. It's reported to cross the BBB, but it's so toxic, with such a narrow therapeutic window, that most people report feeling pretty sick on it.
There will not be “sleep in a pill”. Even the happiest of mitochondria and cells have been entrained for eons to circadian rhythms. (Even benthic deep sea fish sleep; well cyclic rest behavior.)
Long-distance drivers and pilots on long missions have their drugs of choice (e.g., Modafinil), but they are crutches, not replacements.
There is good evidence that fur seals, rays, and some sharks have brain asymmetry in sleep, with half the brain sleeping while the other half keeps an eye open.
Unihemispheric sleep! Convenient.
https://www.science.org/doi/10.1126/science.adf0566
I would look at PQQ, CoQ10, B-complex, GlyNAC or just glycine, AXA1125, R ALA, DCA, creatine; those are known to improve mitochondrial fitness under various mechanisms. Add 99%-100% dark chocolate and exercise, both of which act similarly to PQQ. Theanine for increasing GABA, primary calming neurotransmitter.
I back this up as a human who is doing 90% of these and has a daily A/B test of perceived energy balance and endurance difference depending on using them.
Thank you for the tip about DCA!
If you want to pull an all-nighter then caffeine pills will keep you awake and alert, but no substitute for sleep. I'm sure if you did this for multiple days in a row, you'd be just as messed up as if you forced yourself to stay awake without the pills.