Comment by koeng

15 hours ago

We've known TALENs work for years. For example - https://pmc.ncbi.nlm.nih.gov/articles/PMC4817924/ - from 2015

I worked on a project many years ago to do RNA import into yeast mitochondria (and then hopefully reverse transcribe there). Didn't work, and a lot of the info on RNA import into the mitochondria is... suspect.

Mitochondria engineering is just actually tough. 30 years and no new protocols for getting DNA in there :(

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koeng

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