Comment by fringol__

4 months ago

I think you've missed my key point which is that sex is fundamentally defined by gamete type, and is not a post-hoc clustering of traits. The underlying biological concept is reproduction via anisogamy, which is robust across a multitude of species, humans included. Anisogamy, which you should know as you studied biology, is a reproductive strategy involving the fusion of a small gamete with a large gamete, producing a new individual.

In hermaphroditic species, the two halves of this reproductive system are both embodied in each individual, and are active either consecutively (as with sequential hermaphrodism) or concurrently (as with simultaneous hermaphrodism). In gonochoric species, these are embodied in two distinct classes of individual, via two distinct developmental pathways. Humans are a gonochoric species.

When you claim "sex is a spectrum" or "sex is bimodal", you are confusing sex characteristics with sex. These characteristics are species-specific, whereas sex itself is a cross-species categorization in which sex determination, sexual development, and sex characteristics will vary.

You comment "let's hypothesize that human sex is [always] determined by [XX or XY] chromosomes" and make the argument from this that conditions like Klinefelter syndrome and SRY-negative XY chromosomes disprove that hypothesis. Yes it does, but the hypothesis was flawed in the first place. There is no "human sex" that is different to "sex". More precisely, what you are actually talking about here are the mechanisms of sex determination and sex differentiation in humans. Analyses of DSDs have been very useful in gaining a deeper understanding of these, just as analyses of rare pathologies in other systems do.

Claiming "sex is a spectrum" adds no utility here. It conflates development with definition, and is used for rhetorical ends rather than advancing scientific knowledge. As our conversation has shown, there's not even any consistent understanding of what this spectrum might look like or where individuals should be placed on such a spectrum.

You mention sterility, but this doesn't change someone's sex. The elderly and infertile retain their sex because it's developmental, not performative. This is also why, for example, we can recognize worker bees as female despite them being infertile.

Going back to sports, the available evidence does not show that male athletes weakened through testosterone suppression are equivalent to female athletes. It is not possible to unbuild the body of a human male and rebuild it as female. Your claim that "scientists have already looked into this, and they determined that after two years of hormone therapy transwomen are fairly hard to distinguish from the natural variation in ciswomen for all their metric" misrepresents the research and doesn't take into account what we see performance-wise when these males are allowed to compete in women's sport. Note that while we observe "transwomen" dominating women's competitions, we don't see the same for "transmen" in men's categories, even when they've been on testosterone for many years. This in itself highlights the impact of sex differences in athletic performance.

Let me see if I understand your argument. I'm not sure about several aspects, and it sounds like you have multiple arguments.

[1] Sex is purely defined by gamete size. (Already incorrect, but if that makes the argument easier we can play pretend.) [2] Humans are a gonochoric species. (true) [3] In gonochoric species, unlike simultaneous or sequentially hermaphroditic species, gamete-size generally remains constant throughout the lifetime of the species (also true). [4] Therefore, humans generally maintain the same gamete size throughout an individual’s life (sure, not many people are switching their gamete size throughout their life).

We’re in agreement humans aren’t generally switching gamete sizes through an individual’s lifetime. That would honestly be ridiculous and no one is arguing this. However, while some of these ideas are true and are convenient for talking about various species, it’s not always correct when talking about individuals.

An example of this is using generalized words or labels on anything or anyone. “English-speaking” could mean someone who speaks only English, someone who speaks only a little English. What matters is context and relevance.

Human sexual phenotype can be described by three discrete categories if you want: male, female, intersex. This is what I mean by “spectrum,” I’m literally just mentioning it doesn’t fit the definition of binary (being able to be completely described with 0 or 1 without loss of data). Please see my previous explanation for further details on this. I literally did a proof-by-contradiction.

In individual humans, our genotypes do not always match our phenotypes. For example, XY + No SRY would be functionally identical to XX. XXY and XYY are both viable and happen, and a lot of people might not even realize they don’t have the chromosomes they think they do.

Obviously intersex is about the same proportion of the population as red heads, for context.

So intersex is a perfectly normal and natural human sex phenotype. There are literally human beings living with both gamete sizes for their entire lives, living hopefully happy, healthy lives. This has nothing to do with gonochoric or hermaphroditic species. We’re still a gonochoric species, even if intersex humans exist. Humans aren’t spontaneously changing gamete sizes throughout their lives, but some people literally just have both and have had both since birth. That’s just how it is.

So human sexual phenotypes don’t always match genotypes. They mostly do, probably over 80%, but we’re not honestly sure about the true rate of intersex mostly because it matters so little. As you saw in the textbook chapter I referenced, human sexual phenotype has many factors, but yeah, we can summarize it with three discrete categories: male, female, intersex. That’s again, just how it is. We can debate what to do with intersex, sure, but it honestly doesn’t matter very much.

Your sports argument seems a little strange, I’m honestly not sure I fully understand it:

[1] Gamete size is the only determining factor in human sexual phenotype [obviously incorrect, please see that book chapter] [2] As a society, we divide up sports by sex or gender [yeah, sure, we sometimes do that] [3] Gamete size is relevant in sports [very obviously incorrect, but what you probably mean is that gametes CORRELATE with testosterone, muscle mass differences etc, which is true, and we can measure those correlations] [4] People can’t change their gametes [no one is talking about this, ridiculously irrelevant] [5] Therefore people can’t change their sex?

Trans people exist. We have accepted that there is both biological sex and gender (social construct). Just like genotype and phenotype, they normally match, but sometimes they don’t. I honestly don’t understand why there’s any upset about this, there’s been evidence of this going back pretty far throughout history. We literally get the word hermaphrodite from the ancient Greeks.

So do you only care about transpeople because of sports? There are transmen in the Olympics, so I think they’re doing fine, and I literally linked several papers on transwomen in the Olympics, but I can link them again.

We’ve measured it. This is what science does.

More links: Sex differences and athletic performance. Where do trans individuals fit into sports and athletics based on current research? https://www.frontiersin.org/journals/sports-and-active-livin...

SPORTS AND PERFORMANCE IN THE TRANSGENDER POPULATION: A SYSTEMATIC REVIEW AND META-ANALYSIS

https://www.scielo.br/j/rbme/a/CDkTksYcMPcKYTHGfcJLX4K/?lang...

Transgender Women in the Female Category of Sport: Perspectives on Testosterone Suppression and Performance Advantage

https://link.springer.com/article/10.1007/s40279-020-01389-3

Honestly, if there is some advantage, they’ll measure it, try to understand it, and then change the rules. I’m sure it’s an ongoing discussion. I’m not sure I see your point with all this.

  • > We have accepted that there is both biological sex and gender

    This is close to the real point of dispute, on which there are approximately three main positions, which amount to two political camps because the last two positions drive the same political conclusion (and can be hard to distinguish):

    (1) Sex, socially-ascribed gender, and gender identity are real and distinct things, all of which are (or in the case of active gender should be) multidimensional spectra though they may have something like a bimodal distribution which can naively look binary, and normatively ascribed gender should be aligned to gender identity;

    (2) Sex and ascribed gender and gender identity are real and distinct things, the former is a crisp binary defined by particular physical traits (which traits varies among holders of the belief and over time; gross anatomy was popular, combination of X & Y chromosomes was popular, gamete size is currently the most popular), and normatively both ascribed gender and gender identity should conform to sex; when gender identity specifically does not it is a kind of mental illness, that should be treated and corrected, not accommodated and validated;

    (3) Sex and ascribed gender are real and distinct things with the nature and relationship described in #2, but gender identity does not exist and is a myth invoked to excuse personal moral deviance and/or sexual perversion.

    • Thanks! I'm on the biology side of things, so I tend to avoid going into gender because I don't understand it as well, but the biology seems clear enough. The gender side also makes sense to me broadly, since we have complex and varied cultures, and having a term to talk about different societies also seems helpful. There are multiple languages and cultures with explicit terms for intersex, for example.

      I'm not super clear on why gamete size has become a popular argument for a so-called binary model, since intersex still exists and there are individuals with both gametes. Not to mention, for sports, gamete size seems much less relevant than hormones and natural variation within each sex/gender, and that seems to be the favorite example. Do you have any insights as to why gametes have become a popular argument?

I think you're still missing several key points. Biological sex is more than just gametes. This isn't some weird, niche theory, this is just basic biology. Even if it were just gametes, there are still several intersex conditions. The data is not inherently binary, we measure models by their outputs. This is a common misunderstanding from those not very familiar with how models are used in science and math.

> You comment "let's hypothesize that human sex is [always] determined by [XX or XY] chromosomes" and make the argument from this that conditions like Klinefelter syndrome and SRY-negative XY chromosomes disprove that hypothesis. Yes it does, but the hypothesis was flawed in the first place. There is no "human sex" that is different to "sex". More precisely, what you are actually talking about here are the mechanisms of sex determination and sex differentiation in humans. Analyses of DSDs have been very useful in gaining a deeper understanding of these, just as analyses of rare pathologies in other systems do.

I'm literally talking about human sexual phenotype. That's it. Phenotype does not always match genotype, that's the whole point. Do you understand the difference between genotype and phenotype, because that's half the point of what I've been discussing. You've also missed my entire point about how we measure models in science and what a model is. That whole demonstration was to show you how we actually test models in science.

> Claiming "sex is a spectrum" adds no utility here. It conflates development with definition, and is used for rhetorical ends rather than advancing scientific knowledge. As our conversation has shown, there's not even any consistent understanding of what this spectrum might look like or where individuals should be placed on such a spectrum

I'm not claiming anything. Human sexual phenotype is not binary, as demonstrated through a binary model with proof by contradiction. This is how we evaluate models. Even if we assume a binary model, as I've mentioned, it doesn't actually matter much since there isn't a huge difference between the two genders for most sports. There are measurable differences for others, but that has nothing to do with gamete size and everything to do with different levels of hormones like testosterone, estrogen et cetera, not gametes. Once again, there is significant overlap between the two sexes to start with.

> Going back to sports, the available evidence does not show that male athletes weakened through testosterone suppression are equivalent to female athletes. It is not possible to unbuild the body of a human male and rebuild it as female.

I'm honestly baffled by this statement. No one is "rebuilding" anyone or anything. I'm not actually sure what you mean by this, but this just further demonstrates that we've moved very far away from anything like science. This just sounds like a strange straw man. If you can't even acknowledge that genotype can be different from phenotype, then there's no point in further discussion, this just seems silly.

> Going back to sports...

Men and women have a lot more overlaps than differences. This has been demonstrated. It was actually surprising to me when I first learned about it. We literally do see plenty of transmen in the Olympics, so I'm not quite sure where you're getting this from. Yes, there are differences too, but again, it has nothing to do with actual gametes and mostly it has to do with testosterone and possibly different forms of estrogen etc. What you're calling "sex characteristics."

Here are a few papers: Sex differences and athletic performance. Where do trans individuals fit into sports and athletics based on current research? https://pmc.ncbi.nlm.nih.gov/articles/PMC10641525/

Effect of gender affirming hormones on athletic performance in transwomen and transmen: implications for sporting organisations and legislators https://bjsm.bmj.com/content/55/11/577?ref=goodoil.news

Transwomen might still be a little faster than ciswomen at least a year after hormone therapy, but most of the other metrics were within normal variation after 1-2 years hormone therapy.

  • Sexual reproduction certainly does involve more than just the gametes themselves, but the definition of sex is based on gametes - and that they comprise two distinct classes of cell, in size and form. Otherwise, in gonochoric species, how would anyone know which sex characteristics are female and which are male, and how the female and male sex development pathways differ? And in hermaphroditic species, which anatomical and cellular structures correspond to the female and male halves of the reproductive system. It all comes back to anisogamy. This is the fundamental definition of sex.

    Regarding your second point: that there are variations in phenotype, some of them disordered, doesn't mean that "sex is a spectrum". For DSDs, we can describe them in terms of specific developmental differences compared to normal sex development. These are a set of discrete conditions that can be understood without conjuring up ill-defined spectrums. In fact, DSDs in humans have given those who study developmental biology considerable insight into the mechanisms of human sex development more generally.

    I see after reading those papers you linked that they further illustrate the point I made earlier: that suppression of testosterone weakens males in some ways, but they still retain physiological advantage from testosterone-driven development earlier in their lives. To advocate for the inclusion of such males in female competitions is to advocate for female athletes to compete at a disadvantage.

    If you look at the world records for pretty much every sport, the difference between female and male athletes is very clear. That there exists some overlap between weaker-performing male athletes and higher-performing female athletes doesn't mean that male advantage is significant in almost all sports, especially in ones more reliant on raw strength, such as weightlifting.

    You mention the transmen who compete in the Olympics. This is true but they are competing against other female athletes, e.g. Hergie Bacyadan in the most recent Olympics, competing in women's boxing (and in that same Olympics, two males - controversially - won gold, in two other women's boxing divisions). None of them would even come close to qualifying against elite male athletes.

    • Here is the definition of sex from the Merriam-Webster dictionary:

      1a: either of the two major forms of individuals that occur in many species and that are distinguished respectively as female or male especially on the basis of their reproductive organs and structures 1b: the sum of the structural, functional, and sometimes behavioral characteristics of organisms that distinguish males and females 1c: the state of being male or female 3: genitalia

      Among those who study gender and sexuality, a clear delineation between sex and gender is typically prescribed, with sex as the preferred term for biological forms, and gender limited to its meanings involving behavioral, cultural, and psychological traits. In this dichotomy, the terms male and female relate only to biological forms (sex), while the terms masculine/masculinity, feminine/femininity, woman/girl, and man/boy relate only to psychological and sociocultural traits (gender). This delineation also tends to be observed in technical and medical contexts, with the term sex referring to biological forms in such phrases as sex hormones, sex organs, and biological sex.

      https://www.merriam-webster.com/dictionary/sex

      So what dictionary are you using where "sex" is purely defined by gametes? Please use references and support. I have literally provided studies, textbook chapters, and dictionary entries. You're not actually arguing anything, or if you think you are, you're begging the question. Sex is based on more than gametes and we've known that for decades.

      > I see after reading those papers you linked that they further illustrate the point I made earlier: that suppression of testosterone weakens males in some ways, but they still retain physiological advantage from testosterone-driven development earlier in their lives. To advocate for the inclusion of such males in female competitions is to advocate for female athletes to compete at a disadvantage.

      They literally concluded there wasn't a measurable difference in most of the aspects that they're considering after two years (though there was still an advantage in running after 1 year), so that's a very creative interpretation. There are more studies too, but I can see there's limited point in listing them, since you're reading with your own bias.

      Also, keep in mind with the papers that I provided, the authors of these papers are PhDs in this specialty studying trans individuals. Meaning that people who are way more knowledgeable about all this view trans individuals as exiting, since before you seemed to be denying that. Also please notice, that they aren't measuring gametes, they're measuring the effects of hormone therapy specifically and how that might apply to sports. Rules etc in sports, sure, we can measure and change them, but there are plenty of phds out there studying both gender and sex. If you're trying to argue that nuances in the Olympics and college-level sports means trans can't exist, that seems like very faulty logic.

      > If you look at the world records for pretty much every sport, the difference between female and male athletes is very clear. That there exists some overlap between weaker-performing male athletes and higher-performing female athletes doesn't mean that male advantage is significant in almost all sports, especially in ones more reliant on raw strength, such as weightlifting.

      There are many, many sports where this is not the case and separating between men and women happened late, if at all. Sharp shooting et cetera. There are other sports where yes, there are measurable differences. Testosterone can help in certain sports, that's certainly true, but though that CORRELATES with gametes, it's not absolute, once again demonstrating that what we're actually interested in in sports is testosterone etc, not actual gametes.

      > You mention the transmen who compete in the Olympics. This is true but they are competing against other female athletes, e.g. Hergie Bacyadan in the most recent Olympics, competing in women's boxing (and in that same Olympics, two males - controversially - won gold, in two other women's boxing divisions). None of them would even come close to qualifying against elite male athletes.

      Incorrect. The transmen are competing against other men. Chris Mosier had an injury at the Olympics, which is unfortunate, but he qualified. In 2015 Schuyler Bailar competed in NCAA Div 1 men's team and did pretty well, top 15%. 2018 Patricio Manuel boxed professionally and won. Transathletes are a small percentage of the population and haven't been allowed at the Olympics for very long, so we'll see what happens there.

      Overall, I'm not sure what elite sports has to do with the existence of trans people or human sexual development phenotype or how sex is "only gametes" (or chromosomes, you seem to go between both). The rules in elite sports are always changing, and I'm sure they'll change more. You've essentially assumed your gamete argument is true, despite going against the dictionary, the book chapter I listed, and the studies that I provided, all of which acknowledge trans individuals. This is called "begging the question." If we're going into rhetoric, this is sounding very motte-and-bailey fallacy.

      One thing I will say, is that fundamentally science is about asking questions and measuring phenomena, generally using models etc to try to discern causality (probability and statistics). Science is NOT about telling people who or how to be or denying people's experience. Science can tell us what will happen when we take a drug, not if we "should or shouldn't" take the drug (that's for us to decide). In studying other cultures or experiences, science isn't about labeling "good" or "bad," or erasing experiences we don't understand. For example, we know from studying many other cultures and languages that there are multiple understandings of "sex" across cultures, especially where there are explicit terms for intersex et, which is why terms like "gender" can be useful.

      I'm not sure why you have such a strong reaction to "trans people exist" or why you're trying to act like your views on it are "scientific," when I have provided (1) textbook, (2) dictionary, (3) studies showing that your views that (A) trans people do not exist and (B) sex and sexual phenotype are only determined by gametes are not supported by science and you have fundamentally misunderstood several key aspects of biology and math (binary vs bimodal). I've provided explanations for how we use models in science and how we talk about data. If you're actually interested in learning about this stuff, I hope some of the resources I have listed are helpful. Otherwise, I'm going to assume that this is not a productive discussion of two people trying to understand the world better. I'm sad this is your view of what science is, and if you're ever actually curious about this kind of thing, I hope you find it interesting.

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    • * Edit: I missed one of your points.

      > Regarding your second point: that there are variations in phenotype, some of them disordered, doesn't mean that "sex is a spectrum". For DSDs, we can describe them in terms of specific developmental differences compared to normal sex development. These are a set of discrete conditions that can be understood without conjuring up ill-defined spectrums. In fact, DSDs in humans have given those who study developmental biology considerable insight into the mechanisms of human sex development more generally.

      I already addressed this in a previous comment, but please see Type 1 and Type 2 errors in models. I think the example I used in it was there are no horse-human hybrids (outside of fiction) because we can create a true binary model with horses and humans. That is NOT the case for male and female phenotypes in humans. There are individual humans with both organs, different gametes, different chromosomes, both characteristics etc etc. Obviously-intersex are on the order of red hair in humans, so "it's uncommon" isn't a good counterargument. Again: type 1 and type 2 errors in models.

      For your other points about disorders, let's use red hair again. Red hair isn't "a disorder," even though technically it's a result of a type of melanin dysfunction: "Red hair occurs due to a genetic mutation in the MC1R gene, which affects the production of melanin pigments in hair. This mutation leads to higher levels of pheomelanin, resulting in the characteristic red or ginger hair color." It's a normal, but uncommon phenotype. We understand why it happens and how it occurs, similar to intersex. We don't actually know all the types of intersex or how they interplay with each other, but either way, it doesn't honestly matter. If someone appeared with genuine blue-pigment hair, that would break our model. Red hair is just another phenotype in the spectrum of hair colors. Same with grey hair. Same with intersex.

      We can list all sorts of things as "disorders" or whatever, which is why we use models to discuss data in science, it's a more structured way of evaluating the world. Types of errors are important in evaluating models. There is as-of-yet no binary model for human sexual phenotype. We still generally sort everyone into two discrete categories, but that's what we choose to do as a society, the data itself is not binary. Just to emphasize this once again: models and data how we evaluate and categorize the world using science. Everyone can apply whatever label they want to something. That isn't science. We make progress in science by evaluating models.

      Sex is still very bimodal, no one is arguing that, but fundamentally it's a spectrum. It is not just gametes. We have some of types of intersex listed, sure, but it's also just a normal, uncommon human phenotype.

      Intersex has provided insights and is interesting to study. We're in agreement there.

      For sports, we're not talking chromosomes or gametes at all. They're irrelevant. What they're actually measuring and evaluating is testosterone, muscle mass, etc, which does CORRELATE with gametes, yes. If we're actually concerned about sports, we'll measure and see what happens. But once again, I can assure you that it has nothing to do with gametes or chromosomes or whatever, and a lot more to do with hormones, muscle mass etc. The studies I listed seemed promising, but I'm sure we'll learn more over time.

      I think we're in agreement that ultimately, we want athletes to be able to participate in a way that seems fair, by whatever measure that may be. I'm sure they'll collect more data and we'll decide what we want to do as a society. I am certainly not an expert. The studies I mentioned and several others seem promising. There have been some transmen in the Olympics against other men, though not many. There have also been women who have won gold against men in other sports (skeet I think?) before they were separated. There are obviously several sports where men have measurable advantages to women. For trans-athletes, I suppose we'll see what happens and what the data says.

      Absolutely none of this justifies statements such as "transwomen are men." They are not. Sex and gender are both real, useful terms, and they have their own applications. Also, much like genotype and phenotype, they do not always match. Sexual phenotype does not always match genotype (chromosomes), organs etc.

      We can see and measure the two groups. We can talk about fairness in sports. It is perfectly fine to talk about measuring differences between transwomen and ciswomen. It's perfectly fine to talk about measuring differences between transwomen and (cis or trans) men. It's even perfectly fine to talk about concern for fairness in sports with the inclusion of transwomen and transmen. All of that is fine.

      It is not okay (disrespectful) and incorrect to (1) say that they don't exist (2) say that they're something other than what they identify as. None of that is supported by science. Sex and gender as useful, distinct terms are supported by science. We use those terms to study multiple species, cultures, in whatever forms. Intersex is an uncommon, but well supported phenotype that we literally have records of since ancient times and has been fairly common across many cultures. And across many species. It's honestly so broad it is difficult to define. Literally we have entire hermaphroditic species AND hermaphroditic individuals in non-hermaphroditic species. Similar to homosexuality, it's just a natural phenomenon that happens. You can view trans as part of intersex, or as more of a sociological construct, like gender identity. The data is there.

      If you're actually just concerned for fairness in sports, then you could have talked about the athletes in a respectful way ("I'm concerned about the fairness of transwomen in sports with ciswomen"). You chose not to. In general, your way of thinking sounds more like religion than science, and I've heard it all before already.

      Science isn't a rhetorical weapon. It's a way of studying, evaluating, and communicating about the world, not imposing judgement on it. There is plenty of data supporting trans, gender, intersex, whatever. There are also plenty of respectful ways to discuss this topic, as previously mentioned.

      Why go out of your way to talk about it in a disrespectful way? Why hide behind trying to sound scientific, when it's clear you don't have a background in it? Why the focus on sports?

      I think it's time we stop dancing around the topic and get to the meat of this discussion.

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