Comment by ptrl600

12 days ago

Well until this stuff comes out I'll keep using smuggled FDA-unapproved Novamin toothpaste. Atonement for my neglect

37 comments

ptrl600

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roldie  12 days ago

How does NovaMin / calcium sodium phosphosilicate compare to toothpaste with nanohydroxyapatite in it?

  • gpt5  12 days ago

    It occludes dentinal tubules, helping reduce dentin hypersensitivity. It's a tooth-desensitizing agent helping people who are for example, very sensitive to very cold/hot temperature in their mouth.

    There is evidence that it can foster enamel/dentin mineral gain, but head to head studies shows that it's comparable to regular fluoride toothpaste and not superior. E.g. In a randomized in-situ trial (Caries Research, 2017), adding 5% NovaMin to a 927-ppm SMFP toothpaste did not improve remineralization outcomes vs the same fluoride formula without NovaMin.

    Also, you can find NovaMin in the US (e.g., NUPRO Sensodyne Prophylaxis Paste with NovaMin).

  • ricardobeat  12 days ago

    I don't know if this is everyone's experience, but you get a distinct feeling of smoothness after using it, unlike any other toothpaste. Since NovaMin reacts with saliva to remineralize the tooth you'd imagine it's a stronger bond than directly filling up crevices with nanohydroxyapatite, and studies seem to [slightly] confirm that.

  • tguvot  11 days ago

    anecdotal experience: my wife had somewhat botched dental filling proceedure. it probably damaged her teeth in some way and it became very sensitive for any fluids or foods. they tried to redo it, but it only increased sensitivity further.

    i gave her apagard renamel (with nanohydroxyapatite ). after a few days sensitivity went down and after a few weeks it completely disappeared

ribosometronome  12 days ago

Sensodyne?

  • Waterluvian  12 days ago

    I just learned about this 5 mins ago and did some basic research. Here's what I found:

    - Sensodyne Repair and Protect contains 'NovaMin' (possibly only in some markets; check the ingredients!)

    - NovaMin is the brand name for calcium sodium phosphosilicate

    - It reacts with saliva to form a physical layer of hydroxyapatite on your teeth

    - This layer blocks the tubules that trigger pain from temperature and such

    - It also supports remineralization (how exactly?)

    • mgiampapa  12 days ago

      hydroxyapatite is a mineral like your tooth, that's how it supports remineralization.

      It's actually great stuff and works wonders for tooth sensitivity above and beyond fluoride shellac. I also order it from the more civilized world.

      BioMin is available in the US and is similar, but I don't find it works better and I don't like that it doesn't have fluoride. (I live in an area without fluoride in the water)

      1 reply →

  • LgWoodenBadger  12 days ago

    I used to use sensodyne for cold-sensitive teeth, but they changed ingredients to include something I’m now allergic to. Or I recently developed an allergy to whatever their unchanged ingredients are.

    I have yet to find a replacement for it.

    • EasyMark  12 days ago

      nanohydroxyapatite helps a lot with sensitive teeth, you can even find some brands that also have fluoride in it if you're worried about the nonfluroide versions

annoyingnoob  12 days ago

https://pmc.ncbi.nlm.nih.gov/articles/PMC7068624

  • Etheryte  12 days ago

    I'm not sure what the takeaway is here? If I read that correctly, they only found one study and just reported their results? Is that because there are literally no studies on this worldwide? I find that very hard to believe.

    • 2ap  12 days ago

      A systematic review like this can be helpful, in that it identifies where there are gaps in the literature, and prevents hype - if some studies show evidence of effect, and others do not, even if there are only a few published studies then we know somthing new about the totality of the literature on the subject.

      That said, this particular systematic review has a couple of issues (e.g. I can't find the precise inclusion / exclusion criteria, nor can I find that it has been pre-registered on Prospero or another database).

      I have written a few systematic reviews where there is very little data already availabe, and we use them to explain to funders why we need to do further research on a given topic.

  • zerocrates  12 days ago

    I know there's value to recording the selection process and all that but it's a little funny to have a review that ends up only including one study: at that point just give me a link, not a paper.