Comment by BoingBoomTschak

I use `split[s0][s1];[s0]palettegen=max_colors=64[p];[s1][p]paletteuse=dither=bayer` personally, limiting the number of colors is a great way to transparently (to a certain point, try with different values) improve compression, as is bayer (ordered) dithering which is almost mandatory to not explode output filesizes.