Comment by bonsai_spool
15 days ago
I'm not a specialist but I think there are some stapled peptides that do show appreciable uptake, so the blog post is not a complete history; this review reports bioavailability of up to 70% for some agents.
Nielsen DS et al. 2017. Orally Absorbed Cyclic Peptides. Chemical Reviews.
> this review reports bioavailability of up to 70% for some agents
To save us some skimming, could you specify which ones? (The review covers cyclic peptides that are absorbed by all mammals.)
There are several - I’m not sure why you say cyclic peptides are somehow distinct from other peptides regarding their bioavailability?
All peptides face similar challenges with absorption; the cyclic peptides simply have less liability to proteolysis.
The text covers dozens of agents with varied biochemical properties.
> I’m not sure why you say cyclic peptides are somehow distinct from other peptides regarding their bioavailability?
I'm saying there are peptides on that list that are bioavailable to non-human mammals.