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This is the most fun I've had with Duke Nukem this century https://www.moddb.com/mods/duke-nukem-alien-armageddon

It's a sort of duke roguelike with 100's of potential levels, you play through a a certain random number of them in a run. Also you unlock all sorts of power ups as you progress, enemies also get stronger and get random buffs. + Theyve added a load of mechanics, more weapons, enemies, more playable characters etc.