Comment by Aurornis
8 days ago
I only had time to skim the paper. Notably, the effect is concentration dependent and required high concentrations of THC. The chart shows it really starting in the 0.1uM range and then taking off in the 1uM range.
I don’t know what levels are achieved during normal use but I did find some studies that successfully killed a lot of hippocampal neuronal cells after 6 days at 1uM range. So the levels of THC observed in this study appear to be in the same range where things start getting really disrupted in cells.
In other words, don’t expect to replicate these results with normal recreational use.
I suppose this might be why Willie Nelson is still doing pretty good these days...
It's stress. I'm convinced of it. Little old lady is smoking cigars at 105 years old because she's stress-free. Willie Nelson is looking sharp for his age because he's low-stress. If it helps reduce your personal stress, perhaps...PERHAPS, it's a good thing.
You might have replied to the wrong comment. OP implied it would have no impact
The joke is that Willie Nelson has used very high concentrations simultaneously frying his brain cells and staving off Alzheimer's.
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In vitro studies are not so great for establishing threshold doses surely?
In vitro is great for publication though. If I out bleach and Alzheimer's plaques in a petri dish I bet I could publish that sodium hypochlorite treats Alzheimer's
Reminds me of this classic: https://xkcd.com/1217/
New studies show that research is a leading cause of cancer in rats.
On a serious note: Humans are considered an oncogenic species. https://www.nature.com/articles/s41559-018-0558-7
(You somehow get the full article via https://www.iflscience.com/humans-may-be-causing-cancer-in-o...)
There may not be many constants in this life, especially in this day and age, but I do find it humbling that "there is always an xkcd for that" holds true.
...is there an XKCD relevant to the fact there's always a relevant XKCD?
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quick back of the envelope:
this would require 3 joints of ~ 300 mg cannabis at ~ 30% THC content.
the legendary MTF strain regularily trumpets a 25-30% THC content.
now if bioavailability is 30% that means you need 9 or 10 joints to get a 1 micro molar total dosage. that dose is distributed across body mass.
at this point, i cant say i could conceive of anyone smoking basically an 1/8 ounce of MTA in one day, let alone at one sitting, and doing that for 6 days in a row sounds frightening, not recreational.
https://en.wikipedia.org/wiki/Tetrahydrocannabinol
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I'm pretty sure 0.1 µmol per liter and such absolutely does happen in recreational use. (Recreational use is toxic, destroys memory, etc.)
Can't have Alzheimer's if you don't have much of a brain left.
Can you explain the joke?
If the doses of cannabis required to cure alzheimers would be high enough doses to destroy the rest of one's brain, it makes this finding not very useful, similar to the idea of curing alzheimers by destroying one's brain/
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Sounds like this is more "Pouring bleach on germs kills the germs but it also kills everything else"
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