Comment by opan

I don't use a numpad, but a friend of mine swears by them for playing roguelikes. It makes it much easier to move diagonally in a single turn.

If you play any games with keyboard and mouse, you could bind some letters/numbers from the right half of the keyboard and then place the macropad on the left so you don't have to take your hand off the mouse to hit anything.

For another idea, you could bind pgup/pgdn or scroll wheel up and down for scrolling webpages, IRC backlog, etc.