Comment by JumpCrisscross

6 hours ago

> they are ineffective outside clinical trial setting for treating obesity

This is totally false. I know a number of people who took GLP-1 to treat their obesity and then stopped and have stayed not obese.

6 comments

JumpCrisscross

Reply
rzmmm  2 hours ago

I can't reply elsewhere so I will reply to this again.

> In my friends, all of them stopped taking GLP-1 drugs within 2 years because all of them lost the weight they wanted to. Out of curiosity, what sources lead you to believe this?

Anecdotes like this are interesting but in medicine they are not sufficient to make factual statements about drugs. In meta-analyses there is weight regain which is steeper as more weight is lost during treatment [1].

The weight regain seems to be rather slow, it can take years until the baseline weight is reached.

[1] https://www.bmj.com/content/392/bmj-2025-085304

  • JumpCrisscross  2 hours ago

    > In meta-analyses there is weight regain which is steeper as more weight is lost during treatment

    What does "steeper" mean? The studies I've seen show a net weight loss, even after regain, for the median patient.

    > The weight regain seems to be rather slow, it can take years until the baseline weight is reached

    Maybe. Right now, however, the evidence shows solid effects outside clinical settings. Your original statement was wrong–your sources own refute the claim.

    If you're arguing the effects in the real world haven't consistently been as ridiculous as they were in clinical trials, sure, you get a brownie point. But broadly speaking, these drugs are terrifically effective, both when taken for life and when taken intermittently.

stouset  5 hours ago

If only there were a federal administration whose responsibility it was to collect data about food and drugs so we could rely on something more than anecdotes from random strangers on the Internet.