Comment by teleforce

The idea is to minimize the false positives "the boy who cried wolf" at the same time mitigate, or better eliminate false negatives. The main reason is that based on the physician in-the-loop, the system can be optimized for sensitivity but can be relaxed for specificity. Of course if can get both 100% sensitivity and specificity it will be great, but in life there's always a trade-off, c'est-la-vie.

In our novel ECG based CVD detection system we can get 100% sensitivity for both arrhythmia and ischemia, with inter-patient validation, not the biased intra-patient as commonly reported in literature even in some reputable conferences/journals. Specificity is still high around 90% but not yet 100% as in sensitivity but due to the physician-in-the-loop approach, which is a diagnostic requirement in the current practice of medicine, this should not be an issue.