Comment by adrian_b

It is a very bad choice of words to say that "bipedalism" is a cause for hand specialization.

For hands, it is completely irrelevant how many legs a human has, regardless if a human had used 2, 4, 8, 14 or any other number of legs for walking, the hands would have become specialized.

The reason why the hands acquired specialized roles was that they were no longer used for locomotion, i.e. for brachiation in the trees, like in orangutans or gibbons, but their purpose became holding, controlling and moving various objects from the environment.

It is wrong to say that bipedalism has freed the hands to be used for other activities than locomotion, because the causality was reverse, locomotion became restricted to the hind legs, because the hands were used for other activities, like throwing sticks and stones, so they were no longer available for locomotion.

The strong specialization of the 2 hands has appeared because in most cases when something is transformed with the hands, e.g. bones are broken to get the marrow or stones are knapped to get a cutting edge, one hand must be used to fix in place the object that is processed, while the other hand must move against it, normally with some tool.

For the former role, the left hand became specialized, while for the latter role, the right hand became specialized.

Similar specialization is also seen at other animals where a pair of legs is no longer used for locomotion, but it is used for manipulation, for instance at crabs and lobsters.

So there is no doubt that the specialization of the hands was a necessity when they stopped being used for locomotion. However, it is not known why the right hand became the moving hand and the left hand became the holding hand, and not vice-versa. It could have been a random event or it could have been related to the asymmetry in the locations of the unpaired internal organs, like heart, liver, stomach and so on.