Comment by Sindisil

Upvoted because you've captured the overall point pretty well, but I will say that the Flying V can be pretty dang comfortable seated if you hold in the classical position (i.e., resting on your fretting side thigh). I almost always play standing anyway, but when I do sit, I usually rest the guitar (acoustic or electric) on my left leg anyway because I find it more comfortable.

As with most things guitar, it's mostly about what works for the individual player.