Comment by ethanwillis

  a scientific engine for prediction, design, and discovery that can map proteins across the tree of life, predict their structures, and design new protein binders that function in laboratory experiments. 

So, my issue with this is just like in a lot of the other areas of bio we're not able to explore outside the semantics of what is "known." Even a simpler task of just doing proper assembly is plagued by this. De Novo assembly of an alien/novel organism mixed with samples from other alien organisms would be impossible with what we can do today. Even with things that we're familiar we struggle with metagenomic assembly.