Comment by mmooss
14 hours ago
> overdose is not uncommon
Anecdotally, I hear about it far more in Internet comments like the parent than elsewhere. How common is it?
14 hours ago
> overdose is not uncommon
Anecdotally, I hear about it far more in Internet comments like the parent than elsewhere. How common is it?
Poison center stats, annual, acetaminophen...
https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
Emergency department visits ~56,000
https://pubmed.ncbi.nlm.nih.gov/16294364/
Hospitalizations ~26,000
https://pubmed.ncbi.nlm.nih.gov/16294364/
Deaths ~500 deaths/year
https://pubmed.ncbi.nlm.nih.gov/16294364/
Also, direct from FDA, for those promoting its use with alcohol: "Be aware that severe liver damage may occur if you have three or more alcoholic drinks per day while using acetaminophen." One can infer that stressing the liver prior, then again with tylenol, might be unwise. But by all means, headaches suck. I understand.
Also:
https://www.niaaa.nih.gov/health-professionals-communities/c...
But do not worry. The FDA only specifies that to qualify as risk, requires 'daily' intake of 'three or more drinks'. That is 'daily'. Therefore, it is, if you manage to survive binge drinking several cases of beer and your drinking pattern is null for day1-6, but n amount on day7, perfectly safe to take acetaminophen at will. The documentation does not refute this, therefore it is safe. Only daily drinks, three or more. Binge ok. Only official documentation good true. Inference bad false.
I stand corrected by ctoa!
And to the noble clinical researcher in the house (estearum), I much respec your authorituh. No corruption or monetary influence has ever affected the medical or research field. This I do not dispute. As a chartered researcher, you are an impervious and pure and good person. And honest too. Pharmaceutical industry applies here as well; beyond reproach -- if you're in, you're pure. The notion that they have financial incentives is schizophrenic and despicably paranoid. Anyone who thinks otherwise can have a $200 epipen stuffed in their eye, for free.
I also humbly rescind all my own experience and research. A single I "don't know much" sense from an illustrious professional medical champion was the evidence I needed to retire. Farewell and I shall never think nor speak again. All that cherry pickin really wore me out ;(
And for all:
ScienceDirect S0163834323001317 - A 2023 piece ("Association of regular use of ibuprofen and paracetamol, genetic susceptibility, and new-onset dementia in the older population") that found regular paracetamol use, but not ibuprofen, associated with higher risk of new-onset all-cause dementia, AD, and vascular dementia, independent of genetic risk. But ignore that. Acetaminophen is uncontested by good people. This = bad people https://www.sciencedirect.com/science/article/abs/pii/S01638...
*Mess due to comment throttling.
Didn’t read your links but wonder how they deal with selection bias. People at increased risk for stroke or bleeding disorders, even if just self perceived risk, are told to favor acetaminophen because of the risk inherent in ibuprofen and naproxen sodium.
The Pubmed articles are from 20 years ago. The 2023 JAMA article has some qualified information:
"In 2021, US poison centers received more than 80 000 cases involving an acetaminophen product.1 The National Electronic Injury Surveillance System estimated that 78 414 emergency department (ED) visits occurred annually in the US from January 1, 2006, through December 31, 2007, for overdoses of acetaminophen-containing products.2 In Canada, approximately 4500 hospitalizations occur each year because of acetaminophen overdose.3"
It doesn't tell us risk. Acetaminophen is very widely used, potentially the most widely used drug. I'm not sure what these numbers represent in terms of risk.
What those numbers really don't get into:
~80% of acetaminophen poisoning cases severe enough to end in hospital are intentional suicide attempts.
Those patients also have better outcomes though: family members know what happened, they get them to a hospital, they can take N-acetylcysteine as a timely antidote.
In the unintentional poisoning group, ~90% is from multi-day accumulation, they don't realize they've been poisoning themselves. They have a much higher rate of acute liver failure and death.
https://doi.org/10.1186/cc1475 https://doi.org/10.1016/j.cld.2013.07.001 https://doi.org/10.1097/mcg.0b013e31818a3854
2 replies →
With cost of healthcare, inflation, unemployment, housing crises, wars and whatever else folks have to be thrilled about these days, I am willing to risk assuming alcohol consumption is not going to be on a permanent downward trend. And pain management is far more challenging now than it was 20 years ago, many having no other option beyond NSAIDs for serious problems. That's not hard data, but it is me being quite confident that whatever the numbers were then, won't remain all time highs if they ever were or aspired to be.
Also, I do not work too hard around here, especially with all the corporate aligned types that patrol the area. Folks can do their own research, while they can, before history is rewritten by LLMs and the new internet. Yeah, a lot of articles and papers are getting more difficult to find. And institutional capture is well underway with AI. Newer generations think because they can't find something, it never existed. This is HN, with a karma economy and high price on honesty. I am just leaving occasional marks in the gray zones.