Comment by nekitamo

Yes, Wine was (EDIT: partially) compatible with the Roblox anti-cheat, and there was a period in time where Roblox with its anti-cheat ran on Wine. Eventually, however, a decision was made to block Wine.

EDIT It looks like the Roblox anti-cheat devs themselves explained why Wine was blocked:

https://devforum.roblox.com/t/roblox-on-linux-everything-sum...