Comment by jrogers65

Amphetamine neurotoxicity:

http://en.wikipedia.org/wiki/Amphetamine

>The increase of cytosolic dopamine appears to trigger neurotoxicity, as dopamine readily auto-oxidizes, so that amphetamine or methamphetamine's increase in cytosolic dopamine can lead to oxidative stress in the cytosol that in turn promotes autophagy-related degradation of dopamine axons and dendrites

NMDA antagonists such as magnesium (as mentioned by rms), zinc, DXM, MK-801, Memantine and Ketamine can reduce/prevent tolerance as well as nerotoxicity.

http://www.acnp.org/g4/gn401000166/ch162.htm

> Methamphetamine toxicity is inhibited by a variety of drug treatments, including: ... 3) NMDA receptor antagonists

http://www.socialanxietysupport.com/forum/f30/evidence-for-n...