worth noting that there’s evidence both ways… tumor cells may like it too:
- Loo et al. 2015 found color cancer cells can use it as fuel and blocking the creatine cut metastasis in mice [0]
- zhang et al 20921 found it promoting mouse colon and breast cancer models [1]
not an expert in any way, but i’m guessing it depends on cancer type and there doesn’t seem to be human data either way. as a cautious person w a lot of familial cancer, i cycled off after i looked into it.
Heres a question, this threat is interesting and OpenAI is saying they are at AGI with Astra.... so can we give Astra all the papers on creatine, and all the anecdotal evidence in this thread and get it to produce any new insights to answer why people have different experiences, and why theres some reports of it being cancer fighting and why theres some that arent...?
Just feel if we are at AGI, and its amazing then we should be able to do our own research with it on these topics...
This is such a crazy substance. I'm 43 and I feel like I have more energy than I have ever had before. I started taking it during recovery from a bad ankle fracture since it helps building muscle mass. Once the ankle was better I took up CrossFit, and kept on taking creatine because why not, it helps replenish ATP so I will be able to give the extra-push when working out, I thought.
What is blowing my mind though is that at $dayjob my team is going through a crazy crunch to deliver a very strategic project and some of us are pushing 10-12h days often. I'm in hour 12 today for the second day in a row, and my head is not tired at all. Turns out the brain also uses a lot of ATP too, specially during demanding cognitive tasks so I guess it is creatine that is keeping the engine running smoothly even after so many hours.
I will like once every week or two have a poor night sleep. These days I take twice the dose and I don't feel like I'm sleep deprived at all. Feels like cheating! And apparently no side effects at all so far. Well, maybe I'm working too much.
Mind that, while the "creatine high dose to fight drowsiness" hack works and has no side effects (other than upset stomachs), the lost sleep still does it thing. You don't notice day to day but it will catch up to you eventually in many bad ways.
Definitely! I would not recommend it to make up for lack of sleep for extended periods of time.
One of the things I'm trying to do better lately is to have a good sleep hygiene. Sun in the eyes early in the morning, no caffeine for the first 60 waking minutes of the day (adenosine absorption period), no screens 2 hours before bed and whatnot. Still, some nights I will just wake up in the middle of the night and won't be able to get back to sleep, then it's when I feel creatine helps
The overall fitness is going to definitely have a positive effect on the perceived energy levels (my Vo2 max is at its highest ever). On the other hand, I have been very fit at other times in my life but have never experienced this "my head can just go on" feeling before. I used to take conscious breaks, do NSDR between meetings and other energy-replenishing tricks because I __needed__ them. It feels like now I don't
>I'm 43 and I feel like I have more energy than I have ever had before. I started taking it during recovery from a bad ankle fracture / Once the ankle was better I took up CrossFit, and kept on taking creatine because why not
And how do you know it's the creatine and not ...taking up CrossFit and the benefits to energy and cognitive function exercize brings?
I’m 45 and work out a lot and feel this way without creatine. To the point that this makes me worry it would exacerbate my existing sleep issues (I literally never feel sleepy, I feel exactly the same 24 hours a day).
Some people report less GI distress with creatine HCL but it’s much more expensive.
The GI issues are caused by the creatine absorbing water. This causes your gut to have more water than usual as it follows the creatine through the works… which causes… urgency.
The effect diminishes after you’ve been taking a regular dose for a while, even with just monogydrate (not HCL).
Some people say HCL causes less distress because it doesn’t draw water as much. Others argue that defeats the purpose of taking it.
Monohydrate is studied to death and proven effective, HCL not so much.
Creatine is one of the few if not the only supplements we actually know work. But with that said, my experience is that the bump is there but not world changing. Although it could be placebo, I don't think so because the first time I started taking it I noticed something but didn't make the connection because I noticed it playing basketball and not as much lifting. I could just sprint a lot easier. I recently started taking it again and again I noticed I can sprint easier and not be as spent. Of course you can improve by simply working out regularly, but IMHO the bump you get is obvious.
Thankyou!! I'm sure if you have experience in the medical space this sort of thing seems obvious, but to me (non-medical), the original phrasing was so confusing. Your explanation makes sense.
I started taking a scoop of the Creatine Hydrate from Costco every afternoon because why not. Wife had bought it and the bag was sitting right there.
I honestly don't know whether it made a difference. Sleep didn't get worse, no noticeable metabolic effects. Possibly the "perma tired muscles" I've been suffering from increasingly since about age 57 (I'm an active cyclist) have gotten a bit better, with <50% of days affected rather than >90% last year, but even that is subjective.
If "taking the stuff" means "more uptake" (does it?) and there are other beneficial effects, bring it on.
I can concur on the short-term benefits for longer sets as well as the shorter recovery. Creatine is just one of those no-brainer supplements.
It's safe, cheap, and long-term-study proven to be extremely effective.
You will want to increase your daily hydration (at least for otherwise healthy men, a good sign is that you're "peeing clear") as Creatine does increase water retention.
any recommendation for tendon/joint pain? I'm in my early 30s, and try to lift regularly, but my joints/tendons seem to be the limiting factor when lifting, and not really muscle tiredness/soreness
It sounds you have the hardest part of it underway - consistency.
There's lots of studies - if you can get over 20g per day it is noticeable to the brain and energy. Adding a few grams a week until you're up there I found it noticeable. 20-30g seems to be a noticeable range.
Supplements aren't always like a coffee spike, they build up and sustain quite well.
With so much publishing fraud, low quality of publishing and bogus peer review, I am hard pressed to believe anything that comes out of these journals. I was highly disappointed after reading about Dana-Farber Cancer Institute publishing fraud that endangered so many people lives. Specially papers with 'dietary' research, which are even more bogus. So if someone says, eat X to reduce chance of cancer, I'd ask them to take X put it back where the sun don’t shine.
Cell is not one of "these journals". Publishing to Cell, Nature, Science used to guarantee tenure track for a young professor although I'm not sure if that's still the case.
I know that used to be the case. But its unfortunately not anymore. I am currently In RF and working on some resonators and waveguides. Recently I had the displeasure of reading some papers from top journals to survey what are some new designs that are being pursued.
I was highly disappointed by the low bar of publishing. No characterisation of design, no repeatability study, no comsol files, no fringe field study. Most of the papers read like "we came up with design, tested it with the lowest hanging usecase and there are the results attached with a basic smith chart we made". How am I supposed to have any confidence in anything that is being published like this . The point of public funded research is so I don’t have to research and I can take that research and use/engineer it. But If this is the output then I am not going to spend money and time to do studies to figure out if someone else's research is viable or not because the peer review is broken and publishing bar is in the grave.
I take creatine almost daily for close to 20 years now. Blood work is always perfect. Hours of strength training, cycling and running every week, though.
This might be the best supplement. People over 40 needs CoQ10 (ubiquinol) as well. The energy boost is crazy (I also combine with PQQ, but it's not really proven). Lugol iodine is also the cheapest best supplement ever.
I saw someone handing out samples of creatine at Costco the other day, spouting all sorts of stuff like it's a wonder drug.
It's definitely becoming mainstream.
I've taken it off and on for the past 15 years, the most noticeable effect is about 5lbs of weight gain. I do think it helps gym performance and the increased water retention mames for better muscle definition.
Citation please? Creatine is one of the most studied modern supplements, and I have yet to see anything that says to you'd need to 'take breaks' from it...
Anecdotally, it makes me feel like crap and significantly increased hair shedding. I've seen attestations of both side effects online as well. No idea how or why it could cause either, and the crumminess at least significantly improved very quickly after stopping it. Neither side effect seems to be especially common though.
Not risks but sideeffects that might affect you. I just decided to cut creatine out during summer months, as I sweat significantly more when on creatine (and pee of course, but that is manageable). Now I already sweat more than average joe based on my genetics (yes, I had that checked out by a doctor) but on creatine it became really annoying during hot season. Since creatine definitely allows me to lift heavier and progress, I will just plan around that and put cutting/maintenance phases into the hot season off-creatine, and go back to supplementing it the rest of the year.
I get severe cramping from it (reproducible). All I can find are papers about this being a myth and some reddit threads about other people having this.
I get it too if I don't drink a lot more water. So did many people on my sports team.
Creatine binds to water (making less water available to your muscles) and allows your muscles to work harder (which makes them need more water). So if you're not drinking a lot more water when you're taking creatine, you will get cramps from either dehydration and/or muscle overuse.
But once you're past the loading phase for creatine and getting sufficient hydration, it's supposed to lessen cramps because the water bound to creatine also becomes available for use again as the creatine is used by the body.
I get this unless I drink a lot of water. About 48 fl oz seems to be the right amount for 10g creatine. Sometimes this needs to be combined with a light snack, like a handful of nuts.
Excessively large doses make your stomach and perhaps your kidneys unhappy and supplements being lightly regulated there may be purity issues where the risk is what else is in it.
Near as I can parse it, as a very, very anti-woo person, is as follows:
In a healthy individual with a balanced diet and no deficiencies, there are essentially zero supplements that do anything whatsoever to a measurable degree. Essentially the entire supplement aisle at Whole Foods or whatever is completely woo and useless, and any advertisements are someone trying to make money from you, or some mindless viral craze with no evidence. The exception to this general rule is omega 3s (fish oil is great for this, algae oil is even better given potential heavy metals in fish), protein supplementation if you're weightlifting, and creatine. GLP-1s are a wonder drug that are great if you are not a healthy individual and wish to be.
Please remember that this is a study not the ads and pop-sci articles usually posted here. That means it’s meant to elucidate at most some biological pathways and not to present an overall recommendation. Maybe creatine has strong anti-tumor activity through one pathway and strongly tumor-promoting impacts elsewhere.
Please… just read it as the isolated and interesting insight into biology that it is. It’s a fascinating in vitro result that shows a potentially important role for creatinine in a certain immune response.
As it turns out, no one lets you generate mutant human embryos with deficient creatine receptors, grow them up into adult humans, inject them with melanoma, euthanize them and harvest the tumor cell mass and bone marrow for analysis.
Now I am imagining a 501-C where school children are encouraged to read studies to mice. Children get better at reading technical papers, mice learn more about their options! Win Win!
worth noting that there’s evidence both ways… tumor cells may like it too:
- Loo et al. 2015 found color cancer cells can use it as fuel and blocking the creatine cut metastasis in mice [0]
- zhang et al 20921 found it promoting mouse colon and breast cancer models [1]
not an expert in any way, but i’m guessing it depends on cancer type and there doesn’t seem to be human data either way. as a cautious person w a lot of familial cancer, i cycled off after i looked into it.
[0]: https://pubmed.ncbi.nlm.nih.gov/25601461/
[1]: https://doi.org/10.1016/j.cmet.2021.03.009
also https://www.nature.com/articles/s41467-026-74639-z
Heres a question, this threat is interesting and OpenAI is saying they are at AGI with Astra.... so can we give Astra all the papers on creatine, and all the anecdotal evidence in this thread and get it to produce any new insights to answer why people have different experiences, and why theres some reports of it being cancer fighting and why theres some that arent...?
Just feel if we are at AGI, and its amazing then we should be able to do our own research with it on these topics...
what's stopping you?
This is such a crazy substance. I'm 43 and I feel like I have more energy than I have ever had before. I started taking it during recovery from a bad ankle fracture since it helps building muscle mass. Once the ankle was better I took up CrossFit, and kept on taking creatine because why not, it helps replenish ATP so I will be able to give the extra-push when working out, I thought.
What is blowing my mind though is that at $dayjob my team is going through a crazy crunch to deliver a very strategic project and some of us are pushing 10-12h days often. I'm in hour 12 today for the second day in a row, and my head is not tired at all. Turns out the brain also uses a lot of ATP too, specially during demanding cognitive tasks so I guess it is creatine that is keeping the engine running smoothly even after so many hours.
I will like once every week or two have a poor night sleep. These days I take twice the dose and I don't feel like I'm sleep deprived at all. Feels like cheating! And apparently no side effects at all so far. Well, maybe I'm working too much.
Mind that, while the "creatine high dose to fight drowsiness" hack works and has no side effects (other than upset stomachs), the lost sleep still does it thing. You don't notice day to day but it will catch up to you eventually in many bad ways.
Definitely! I would not recommend it to make up for lack of sleep for extended periods of time.
One of the things I'm trying to do better lately is to have a good sleep hygiene. Sun in the eyes early in the morning, no caffeine for the first 60 waking minutes of the day (adenosine absorption period), no screens 2 hours before bed and whatnot. Still, some nights I will just wake up in the middle of the night and won't be able to get back to sleep, then it's when I feel creatine helps
Edit: Typo
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It has an especially noticeable effect if you're a vegetarian. I'm a lifelong vegetarian, and high doses of it for me are a crazy cognitive enhancer.
That's because creatine is missing in vegetarian diets. It is found in beef. Something to consider if you are thinking about going vegetarian.
Oh I’ve been mostly plant based for years, maybe that helps explaining the difference
is it possible that this is the bump due to your workouts and not plainly creatine ?
I take creatine daily but when I'm working out more than a couple of weeks, i feel much better than on weeks when I skip working out.
The overall fitness is going to definitely have a positive effect on the perceived energy levels (my Vo2 max is at its highest ever). On the other hand, I have been very fit at other times in my life but have never experienced this "my head can just go on" feeling before. I used to take conscious breaks, do NSDR between meetings and other energy-replenishing tricks because I __needed__ them. It feels like now I don't
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great question. Can I take creatine and skip the workout hassle?
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>I'm 43 and I feel like I have more energy than I have ever had before. I started taking it during recovery from a bad ankle fracture / Once the ankle was better I took up CrossFit, and kept on taking creatine because why not
And how do you know it's the creatine and not ...taking up CrossFit and the benefits to energy and cognitive function exercize brings?
I take creatine daily, have done for well over a year. I also run 5-6 days a week and lift twice a week.
I’ve previously stopped taking it for a couple months and noticed no real difference in physical or mental ability.
You may not have taken enough. You need 15-20g/day for mental benefits. And long term, at least 2+ weeks.
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The only difference I notice is a small increase in muscle strength after taking it for a month or so.
I’m 45 and work out a lot and feel this way without creatine. To the point that this makes me worry it would exacerbate my existing sleep issues (I literally never feel sleepy, I feel exactly the same 24 hours a day).
Any tips on GI impact? I pair mine with food and lots of water and it's improved but wondering if there's any more I should be doing
Some people report less GI distress with creatine HCL but it’s much more expensive.
The GI issues are caused by the creatine absorbing water. This causes your gut to have more water than usual as it follows the creatine through the works… which causes… urgency.
The effect diminishes after you’ve been taking a regular dose for a while, even with just monogydrate (not HCL).
Some people say HCL causes less distress because it doesn’t draw water as much. Others argue that defeats the purpose of taking it.
Monohydrate is studied to death and proven effective, HCL not so much.
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Anything over 5g is hard on my stomach. I take it in my protein shake in the morning and dont notice any issues.
I took double the dose once and I regretted it. I was in the bathroom pretty often that day.
Do you take the standard 5g or something else? What's your weight?
~5g most days, ~10g if I didn't sleep well. I'm currently 68kg
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Have you tried stopping creatine? How do you know it's the creatine?
I've been taking it for almost a month and I plan to stop to see if I notice any change back that would make me want to start taking creatine again.
Creatine is one of the few if not the only supplements we actually know work. But with that said, my experience is that the bump is there but not world changing. Although it could be placebo, I don't think so because the first time I started taking it I noticed something but didn't make the connection because I noticed it playing basketball and not as much lifting. I could just sprint a lot easier. I recently started taking it again and again I noticed I can sprint easier and not be as spent. Of course you can improve by simply working out regularly, but IMHO the bump you get is obvious.
It's beyond crazy, lol. How many grams are you doing a day?
It has replaced in some ways caffeine for me.
The part of where creatine wipes out sleep deficit sounded like a stretch, but it definitely helps.
And this is surely thanks to Creatine. Amazing!
- Enhances ANTI-tumor... sounds good - ANTI-tumor immunity... sounds bad? - Read first few paragraphs as a typical medical rube, got nowhere
So, creatine = good?
"But you get your choice of toppings." "That's good!" "The toppings contain potassium benzoate... ...that's bad."
Can I go now?
Don’t worry, if you aren’t confused enough there’s also this to send you through another cycle! https://pubmed.ncbi.nlm.nih.gov/33811821/
That link sent me into a neverending redirect and reCAPTCHA loop, so very confused.
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"Immunity" = "immune system activity." "Anti-tumor immunity" = "immune system activity against tumors."
Thankyou!! I'm sure if you have experience in the medical space this sort of thing seems obvious, but to me (non-medical), the original phrasing was so confusing. Your explanation makes sense.
Original title may be clearer?
Creatine uptake promotes dendritic cell activation and enhances antitumor immunity
Original title is too long, I had to shorten it
I mean the summary ends with pretty clear message
> …and support the use of creatine supplementation as a strategy to augment DC-based cancer immunotherapy.
So it seems that from this research the outcome is indeed creatine = good
Anti-missile shielding
I started taking a scoop of the Creatine Hydrate from Costco every afternoon because why not. Wife had bought it and the bag was sitting right there.
I honestly don't know whether it made a difference. Sleep didn't get worse, no noticeable metabolic effects. Possibly the "perma tired muscles" I've been suffering from increasingly since about age 57 (I'm an active cyclist) have gotten a bit better, with <50% of days affected rather than >90% last year, but even that is subjective.
If "taking the stuff" means "more uptake" (does it?) and there are other beneficial effects, bring it on.
If you start lifting weight at the gym you quickly will feel the difference: your muscles recover much better during the set breaks.
I can concur on the short-term benefits for longer sets as well as the shorter recovery. Creatine is just one of those no-brainer supplements.
It's safe, cheap, and long-term-study proven to be extremely effective.
You will want to increase your daily hydration (at least for otherwise healthy men, a good sign is that you're "peeing clear") as Creatine does increase water retention.
any recommendation for tendon/joint pain? I'm in my early 30s, and try to lift regularly, but my joints/tendons seem to be the limiting factor when lifting, and not really muscle tiredness/soreness
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It has a noticeable effect if you lift.
Creatine is one of the most studied supplements.
It sounds you have the hardest part of it underway - consistency.
There's lots of studies - if you can get over 20g per day it is noticeable to the brain and energy. Adding a few grams a week until you're up there I found it noticeable. 20-30g seems to be a noticeable range.
Supplements aren't always like a coffee spike, they build up and sustain quite well.
I thought around 5g is the recommended daily dose?
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With so much publishing fraud, low quality of publishing and bogus peer review, I am hard pressed to believe anything that comes out of these journals. I was highly disappointed after reading about Dana-Farber Cancer Institute publishing fraud that endangered so many people lives. Specially papers with 'dietary' research, which are even more bogus. So if someone says, eat X to reduce chance of cancer, I'd ask them to take X put it back where the sun don’t shine.
Cell is not one of "these journals". Publishing to Cell, Nature, Science used to guarantee tenure track for a young professor although I'm not sure if that's still the case.
I know that used to be the case. But its unfortunately not anymore. I am currently In RF and working on some resonators and waveguides. Recently I had the displeasure of reading some papers from top journals to survey what are some new designs that are being pursued. I was highly disappointed by the low bar of publishing. No characterisation of design, no repeatability study, no comsol files, no fringe field study. Most of the papers read like "we came up with design, tested it with the lowest hanging usecase and there are the results attached with a basic smith chart we made". How am I supposed to have any confidence in anything that is being published like this . The point of public funded research is so I don’t have to research and I can take that research and use/engineer it. But If this is the output then I am not going to spend money and time to do studies to figure out if someone else's research is viable or not because the peer review is broken and publishing bar is in the grave.
Note that they gave the mice 10mg per day, which is around 3g per day for a 70kg human - i.e. a normal dose.
I take creatine almost daily for close to 20 years now. Blood work is always perfect. Hours of strength training, cycling and running every week, though.
This might be the best supplement. People over 40 needs CoQ10 (ubiquinol) as well. The energy boost is crazy (I also combine with PQQ, but it's not really proven). Lugol iodine is also the cheapest best supplement ever.
The whole creatine craze reminds me of Vitamin D a couple of years ago. Which also sounded harmless, but can go very wrong if not careful
> but can go very wrong if not careful
This is vague and doesn't explain anything. Can you share any references that communicate what you're thinking about?
They're talking about vitamin D, which accumulates due to being fat soluble and is indeed toxic at a certain level[1]
It became something of a panacea nutrient, recently around COVID.
1. https://en.wikipedia.org/wiki/Vitamin_D_toxicity
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Unless you have specific issues, creatine is pretty easily excreted in excess, unlike fat-soluble vitamin D.
This doesn't mean you can just pound it, but for the most part it just becomes waste product.
Craze? People have been taking creatine for decades. It's really well studied and is quite safe.
I saw someone handing out samples of creatine at Costco the other day, spouting all sorts of stuff like it's a wonder drug.
It's definitely becoming mainstream.
I've taken it off and on for the past 15 years, the most noticeable effect is about 5lbs of weight gain. I do think it helps gym performance and the increased water retention mames for better muscle definition.
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You definitely want to take breaks from Creatine. It’s not something people should take year around.
I understood the idea that you need to cycle creatine to be a myth.
Citation please? Creatine is one of the most studied modern supplements, and I have yet to see anything that says to you'd need to 'take breaks' from it...
Are there risks to creatine?
As it was mentioned elsewhere it might make existing cancers worse, and decrease survivability. Cancer seems to love it.
https://pubmed.ncbi.nlm.nih.gov/25601461/ https://doi.org/10.1016/j.cmet.2021.03.009
More accessible video: https://www.youtube.com/watch?v=tcMgHncZVIw
Anecdotally, it makes me feel like crap and significantly increased hair shedding. I've seen attestations of both side effects online as well. No idea how or why it could cause either, and the crumminess at least significantly improved very quickly after stopping it. Neither side effect seems to be especially common though.
Not risks but sideeffects that might affect you. I just decided to cut creatine out during summer months, as I sweat significantly more when on creatine (and pee of course, but that is manageable). Now I already sweat more than average joe based on my genetics (yes, I had that checked out by a doctor) but on creatine it became really annoying during hot season. Since creatine definitely allows me to lift heavier and progress, I will just plan around that and put cutting/maintenance phases into the hot season off-creatine, and go back to supplementing it the rest of the year.
Generally no, it's expensively studied and has had daily consumption to be safe for upto 5 years at least (studies haven't generally gone longer).
That being said some people do have adverse effects to supplementation, e.g. excessive water retention, bloating, stomach discomfort, &c.
So try it, if you have a bad reaction stop.
Maybe
https://www.frontiersin.org/journals/nutrition/articles/10.3...
I get severe cramping from it (reproducible). All I can find are papers about this being a myth and some reddit threads about other people having this.
I get it too if I don't drink a lot more water. So did many people on my sports team.
Creatine binds to water (making less water available to your muscles) and allows your muscles to work harder (which makes them need more water). So if you're not drinking a lot more water when you're taking creatine, you will get cramps from either dehydration and/or muscle overuse.
But once you're past the loading phase for creatine and getting sufficient hydration, it's supposed to lessen cramps because the water bound to creatine also becomes available for use again as the creatine is used by the body.
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I get this unless I drink a lot of water. About 48 fl oz seems to be the right amount for 10g creatine. Sometimes this needs to be combined with a light snack, like a handful of nuts.
Did you try different sources I do not trust some of the stuff out there and often wonder if these supplements aren’t just generic white powder…
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Essentially none. Creatine supplementation is a good idea for most people, especially vegans/vegetarians.
Why especially those?
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It can make you hold more water weight so you should drink more water in response.
i personally have problems with tinnitus and hearing loss, and creatine use tends to trigger it due to water retention so i stay off the stuff.
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Potentially lots poopies.
Worse beach looks
Creatine causes intramuscular water increases, not subcutaneous. Doesn't actually have a negative impact here.
Excessively large doses make your stomach and perhaps your kidneys unhappy and supplements being lightly regulated there may be purity issues where the risk is what else is in it.
But it's pretty safe at recommended doses.
None
So, creatine and creatine-phosphate are used in particular by muscle cells for quick energy re-supply.
I would be highly sceptical of the claim "antitumor immunity". It sounds like an ad.
Before you get scooping, see also "Caffeine and progression of Parkinson’s disease: A deleterious interaction with creatine" https://pmc.ncbi.nlm.nih.gov/articles/PMC4573899/
Real question, if Creatine is actually this good, what product specifically are people using?
related: https://news.ycombinator.com/item?id=48346947
(I regret posting that blog post, but the study and discussion is interesting)
So what’s the latest? That everyone should take creatine and GLP-1s?
Near as I can parse it, as a very, very anti-woo person, is as follows:
In a healthy individual with a balanced diet and no deficiencies, there are essentially zero supplements that do anything whatsoever to a measurable degree. Essentially the entire supplement aisle at Whole Foods or whatever is completely woo and useless, and any advertisements are someone trying to make money from you, or some mindless viral craze with no evidence. The exception to this general rule is omega 3s (fish oil is great for this, algae oil is even better given potential heavy metals in fish), protein supplementation if you're weightlifting, and creatine. GLP-1s are a wonder drug that are great if you are not a healthy individual and wish to be.
Adverse side effects of creatine are generally less severe than GLP-1s
With a peptide chaser.
I wasn’t being facetious. I seriously am asking if everyone should actually take creatinine and GLP-1.
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Please remember that this is a study not the ads and pop-sci articles usually posted here. That means it’s meant to elucidate at most some biological pathways and not to present an overall recommendation. Maybe creatine has strong anti-tumor activity through one pathway and strongly tumor-promoting impacts elsewhere.
Please… just read it as the isolated and interesting insight into biology that it is. It’s a fascinating in vitro result that shows a potentially important role for creatinine in a certain immune response.
There’s just so much evidence that creatine is something people should take daily, and now this?
I’ve taken to snorting it. Straight to the brain it goes!
you joke, but that is a real issue for some
https://en.wikipedia.org/wiki/Cerebral_creatine_deficiency
I've been smoking mine
...in mice.
As it turns out, no one lets you generate mutant human embryos with deficient creatine receptors, grow them up into adult humans, inject them with melanoma, euthanize them and harvest the tumor cell mass and bone marrow for analysis.
Unhelpful. Sure, we can't do the same study in humans, but that doesn't mean the results are inherently applicable to humans
Did you read it at all?
> Notably, creatine uptake similarly boosted the activation and immunostimulatory function of human monocyte-derived DCs.
Fair. Missed that bit tbh.
Imagine how healthy mice in general could live, if they were able to read all these research papers about themselves.
Now I am imagining a 501-C where school children are encouraged to read studies to mice. Children get better at reading technical papers, mice learn more about their options! Win Win!
They already do in their own dimension, all that dying and running down the wrong track in those mazes is just to befuddle us silly hominids.
Source: https://hitchhikers.fandom.com/wiki/Mice
I, for one, welcome our future inmice overlords.